Igtropin igf 1 lr3
Igtropin igf 1 lr3 DESCRIPTION
Synthetic peptide IGF-1 LR3 is lengthened analogue of endogenous peptide hormone IGF-1 (human insulin-like growth factor 1). Unlike regular IGF-1, its prolonged version IGF-1 LR3 haves an arginine instead of a glutamic acid at the third position in its amino acid sequence (“arginine 3”), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (“long”). Total length of its amino acid chain is 83 amino acids unlike 70 amino acids of regular IGF-1.
IGF-1 LR3 still retains its strong pharmacological activity as an agonist of the IGF-1 receptor, but due to the mentioned modifications has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs) unlike regular IGF-1 does have, and also has improved metabolic stability. As a result, it is approximately three times more potent than IGF-1, and possesses a significantly longer half-life of about 20 hours. The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.
CLINICAL TRIALS AND IGF-1 RESULTS
Clinical trials have shown, that Igtropin binds with high-affinity to IGF-1 receptor (IGF1R), and due to its significantly reduced binding to IGF-binding proteins.
Even more metabolic stable and potent than regular IGF-1 in stimulating hypertrophy and proliferation of cells. IGF LR3 can be suitable treatment in catabolic states (using the peptide to induce anabolism in catabolic conditions such as muscular dystrophy).
IGF-1 has a strong ability to maintain and build muscle. In addition to a direct anabolic effect on skeletal muscle, the production of more IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells) – real growth of new muscle cells. Peptide hormone IGF-1 is the only hormone that can do this.
SCIENTIFICALLY INVESTIGATED POSSIBLE BENEFITS OF IGF-1
Overall regeneration of the whole body (incl. internal organs), increased cellular repair
Anti-aging effects, rejuvenation and the ability to slow-down the aging
Increased collagen production, healthier skin, helping to smooth out wrinkles
Strong anabolic effect / promoting muscle growth, strength and performance
Ability to induce muscle hyperplasia – the growth of new muscle cells
Strong anti-catabolic effect / protection against muscle wasting
Increased bone mineral content / greater bone mineral density
Improved cognitive functions, improves learning and memory
Promotes regeneration of the nervous system and brain health
May reduce risk of heart & cardio-vascular diseases
Strengthened immune system
Improved gut health